Micromanipulation specialist, Scientifica is using peristaltic pumps
supplied by Watson-Marlow Bredel in a new line of pharmaceutical drug
testing and discovery systems. Based on a technique called
'electrophysiology', these systems include a perfusion process in which
precise amounts of the experimental compounds are dispensed on to the
cells under test, in order to assess their effectiveness. The drug flow,
in this case, is controlled and managed by a three-channel peristaltic
pump. The unit accepts manifold tubing in a variety of bore sizes and
flow rates can be adjusted to alter the speed of perfusion. This enables
different drug solutions to flow at different rates - an essential
function when handling drug concentrations that are hard to manipulate.
The fluids do not come into contact with the pump itself, so there is no
instrument contamination and no need to clean the pump internals. Only
the tube needs changing.
The perfusion application is at the heart of the system and thus its
component parts have to be extremely reliable. In essence it is a
computer controlled valve management system, which can apply a
potentially unlimited amount of agents to a single cell or group of
cells. Fluid control is achieved via a series of two- or three-way pinch
valves (which again have the benefit of non-contamination) in conjunction
with the peristaltic pump.
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